Brain inflammation & associated autism disorders

In brief, autism is a group of disorders with genetic and environmental causes. ASD children have evidence of abnormalities in the brain during the first 2 years of life. This may be attributed to inflammation, and the lymph flow from the meningeal lymphatic system in the brain may be a factor. ASD children appear to have increased cerebrospinal fluid (CSF) in the folds and spaces around the brain (extra-axial spaces). Increased extra-axial spaces correlate with an increase in severity of autism symptoms, and the reason for the increase in the fluid has…

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Immune dysfunction in autism

Autism spectrum disorders (ASD) are developmental disorders affecting 1:33 children, and which appear to be associated with a variety of complex immune dysregulations including autoimmunity. The enzyme, alpha-N-acetylgalactosaminidase (Nagalase) deglycosylates Vitamin D Binding Protein (VDBP) rendering it incapable of activating macrophage defenses.  Increased Nagalase activity has been associated with a variety of malignancies, immune disorders and viral infections. Macrophage activating factor (MAF) has been repeatedly published as an intervention to lower serum Nagalase activity for a variety of cancer and HIV patients. MAF is a naturally occurring protein with well-established safety and…

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Reduction in the symptoms known as autism

The most common reported improvements concern cognitive abilities: attention and focus, learning and understanding, receptiveness and awareness of the environment and people around them, in addition receptive language (understanding new and complex sentences from parents and adults) and expressive language (ability to pronounce the first words, or increase the number of known words, or improve imitation, language and speech fluency), social skills (willing to interact and communicate with peers). Finally, they also reported improvements in behaviour: less hyperactive, less stereotypical, more cooperative and compliant. The 4 children who had side effects showed…

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